Figure 2.

(a) The LSTM-RNN model specializes in capturing sequential information. Besides three gates (input, forget, and output), it comprises two internal states: memory cell states (e.g. keeping/discarding formation) and hidden states. X represents the radiation input and Y represents the anti-PD-L1 input, respectively. (b) The timing diagram of the combined therapy in our study. For immunotherapy, either anti-PD-L1 or isotype control was administered. For radiation, different doses were delivered (10, 15, 20, 40 Gy). The first pulse of radiation was always delivered 14 days after the implantation. Tumor volume measurements were carried out sequentially on certain days.