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. 2024 Apr 8;7:427. doi: 10.1038/s42003-024-06111-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Study flowchart. b UMAP plots showing the main cell cluster distribution of the developing and aging human lungs. c Expression of classical marker genes used to define the main cell clusters. d Dot plots showing the specific marker genes of the main cell clusters. e The number of cells of each main cell cluster. f UMAP plots showing the cell distribution in 5 phases. g For each of the 5 phases, the fraction of cells originating from each of the 10 main cell clusters.