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. 2024 Apr 8;7:427. doi: 10.1038/s42003-024-06111-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a UMAP plots of fibroblast (FB) (left). Proportion of fibroblast subclusters in 5 groups (right). b Dot plots of specific marker genes of fibroblast. c The age-associated changes of transcriptional noise of fibroblast. d Gene ontology enrichment analysis of gene expression in cluster 2 of fibroblast (development). e Gene ontology enrichment analysis of gene expression in cluster 6 of fibroblast (development). f Gene ontology enrichment analysis of up (top part, red)/down (bottom part, blue)-regulated gene expression in fibroblast. g Elastin synthesis (GO: 0071953) score of fibroblasts between 5 groups. h Collagen catabolic (GO: 0030574) score of fibroblasts between 5 groups. i Masson-stained sections of lung tissues between 5 groups and relative fibrosis area of the lung tissues shown as the means ± SD, tested by two-tailed t-test. *p < 0.05. j Relatively expression of FTL in fibroblast in single-cell analysis. k The expression of FTL in fibroblast of immunofluorecence staining. The choice of ANOVA tests was based on the results of Shapiro–Wilk normality test. Dunnett tests were used to inter-group comparison. **p < 0.01, ****p < 0.0001.