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. 2024 Apr 8;15:2999. doi: 10.1038/s41467-024-47097-8

Fig. 8. Ribose-5-phosphate synthesis and utilization in Toxoplasma in disparate environments.

Fig. 8

a, b Potential routes of ribose-5-phosphate (R5P) synthesis—SBPase-TKT, TAL-TKT, TKT-RuPE-RPI and oxiPPP-RPI pathways. R5P produced via PPP is a substrate for phosphoribosyl-pyrophosphate synthetase (PRPS) to make PRPP, a crucial precursor for nucleotide biogenesis. c SBPase disruption enables the R5P synthesis through other routes. d The ΔsbpaseΔtal strain meets its need for R5P via the TKT-RuPE-RPI, oxiPPP-RPI and TKT-mediated pathways. However, None of these routes appear to be adequate for parasite growth. e The supply of R5P depends on the oxiPPP-RPI and TKT-mediated pathways in the ΔsbpaseΔtalΔrupe strain. f TKT cooperates with SBPase, TAL and RuPE-RPI pathways to satisfy R5P requirements. Mutants lacking TKT rely only on the oxiPPP-RPI pathway for supplying R5P, which may not be sufficient. g Deletion of PRPS blocks the biosynthesis of PRPP and parasite growth, even though PPP can provide R5P.