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. 2024 Apr 8;14:8176. doi: 10.1038/s41598-024-58375-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CUR ameliorates gait abnormalities in rats caused by KOA. (A) Effect of KOA on the maximum contact area of rats. Maximum contact area (cm²) represents the maximum surface area of the claw in contact with the glass plate. (B) Effect of KOA on the mean intensity of rats. Mean intensity represents the average intensity of the claw in contact with the glass plate. (C) Effect of KOA on the swing of rats. Swing (s) is the time that the claw did not make contact with the glass plate during a walking cycle. (D) Effect of KOA on the stand of rats. Stand (s) is the time that the claw is in contact with the glass plate. (E) This is the print view of the claw on the glass plate. Control represents the blank control rats. Sham represents sham-operated group rats. KOA represents the knee osteoarthritis model group rats. KOA + CUR represents the treated group rats with feeding CUR. *P < 0.05, **P < 0.01, ***P < 0.001. All data are expressed as mean ± SD, n = 8 for each group.