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. 2024 Apr 8;10:167. doi: 10.1038/s41420-024-01939-y

Fig. 4. TM attenuates the motor deficits in A53T α-syn mice.

Fig. 4

The mice were stereotactically injected with AAV-TM or AAV-Vector, their motor behavioral and cognitive abilities were tested 30 days after injection. a Body suspension test was used to detect mouse muscle by recording the time in which the mice hold on the rung. n = 8 mice per group. Data are mean ± SEM, and a one-way ANOVA followed by Tukey’s multiple comparison test was used for statistical analysis. b–d The motor activity of mice was detected via the distance in center (b), times to entire center region (c) and time of mice (d) spent in center. n = 8 mice per group. Data are mean ± SEM, and a one-way ANOVA followed by Tukey’s multiple comparison test was used for statistical analysis. e, f The balance and coordination of mice detected by pole test. The time of mice with TM overexpression to turn (e) and descend (f) was recorded in this experiment. n = 8 mice per group. Data are mean ± SEM, and a one-way ANOVA followed by Tukey’s multiple comparison test was used for statistical analysis. g The exercise ability of mice was measured by the rotarod test, the latency to fall from rotarod during the test in 3 consecutive days. n = 8 mice per group. Data are mean ± SEM, and a one-way ANOVA followed by Tukey’s multiple comparison test was used for statistical analysis. h, i The special memory of mice detected by Y maze, the time spent in the novel arm (h) and the number of entries (i) in Y-maze test. n = 8 mice per group. Data are mean ± SEM, and a one-way ANOVA followed by Tukey’s multiple comparison test was used for statistical analysis. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns not significant.