Figure 2.

Ingenuity Pathway Analysis prediction of dysregulated chemoattractant ligand genes in LPS-exposed vs LPS+I3C treated mice. Mice were exposed to LPS to induce ARDS followed by treatment with I3C as described in the Methods and cells from the lungs were screened as follows. (A) scRNAseq t-SNE heatmap expression of CCR2, CCR5, and CXCR2. (B) IPA pathway prediction graphical summary of local gene dysregulation associated with immune cell trafficking functions when comparing LPS+Veh vs. LPS+I3C.