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. 2024 Mar 26;14:1364199. doi: 10.3389/fonc.2024.1364199

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Copyright © 2024 Mak, Li, Chan, Leung, Cheuk, Yuen, So, Ha and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Case 3. (A), The bone marrow demonstrates dysgranulopoiesis (green arrow) and increase in blasts (blue arrow). Wright-Giemsa stain, 400 X magnification. (B), The bone marrow also demonstrates dysmegakaryopoiesis (purple arrow). Wright-Giemsa stain, 400 X magnification. (C) Karyotyping reveals a clone with monosomy 7. (D), The trephine biopsy shows non-hemic cellular infiltration. Hematoxylin & Eosin stain, 200 X magnification. Immunohistochemical staining shows the abnormal infiltration is positive for synaptophysin (E) and chromogranin (F), and negative for NeuN (G), which is compatible with marrow involvement by medulloblastoma. 200 X magnification.