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. 2024 Mar 26;4:1323432. doi: 10.3389/fneph.2024.1323432

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Copyright © 2024 Andeen, Kung and Avasare

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neural epidermal growth factor-like 1 (NELL1) membranous nephropathy with (A) “stiff” appearing capillary loops with faint rarefactions of the glomerular basement membrane and subepithelial immune deposits (arrows, Jones stain 400x). (B) By immunofluorescence, there is segmentally distributed granular peripheral capillary wall staining for polyclonal IgG. (C) By electron microscopy, irregularly distributed subepithelial immune deposits are present, with associated podocyte foot process effacement (direct magnification 1900x). (D) By immunohistochemistry, there is corresponding incomplete capillary wall staining of immune deposits for NELL1.