Table 2.
Patient characteristics
| Characteristic | Sotrovimab (n=599) | Untreated (n=5191) |
| Age | ||
| Mean (SD) | 57.4 (15.6) | 52.5 (17.6) |
| Median (Q1–Q3) | 58 (46–70) | 53 (40–65) |
| Age group ≥65 years, n (%) | 211 (35.2) | 1302 (25.1) |
| Female sex, n (%) | 303 (50.6) | 2459 (47.4) |
| Ethnicity, n (%) | ||
| White | 309 (54.3) | 2556 (49.2) |
| Asian/Asian British | 136 (23.9) | 1167 (22.5) |
| Black/Black British | 69 (12.1) | 768 (14.8) |
| Mixed | 18 (3.2) | 189 (3.6) |
| Other | 37 (6.5) | 277 (5.3) |
| Unknown | 30 (5.0) | 234 (4.5) |
| Vaccination status, n (%) | ||
| Fully* | 560 (93.5) | 4536 (87.4) |
| Not fully | 39 (6.5) | 655 (12.6) |
| Time since last vaccination (days) | ||
| Mean (SD) | 131.6 (90.3) | 127.2 (89.3) |
| Median (Q1–Q3) | 112 (66–165) | 97 (49–167) |
| Time to treatment (days) | ||
| Mean (SD) | 1.9 (1.6) | 1.8 (1.6) |
| Median (Q1–Q3) | 1 (1–2) | 1 (1–2) |
| Highest-risk conditions, n (%) | ||
| Down’s syndrome | 6 (1.0) | 138 (2.7) |
| Solid cancer | 72 (12.0) | 487 (9.4) |
| Haematological disease and stem-cell transplant recipients | 71 (11.9) | 400 (7.7) |
| Renal disease | 254 (42.4) | 1094 (21.1) |
| Liver disease | 41 (6.8) | 487 (9.4) |
| IMID | 45 (7.5) | 512 (9.9) |
| Immune deficiencies | 75 (12.5) | 1250 (24.1) |
| HIV/AIDS | 60 (10.0) | 1149 (22.1) |
| Solid-organ transplant | 72 (12.0) | 244 (4.7) |
| Rare neurological conditions | 81 (13.5) | 797 (15.4) |
| Number of highest-risk conditions, n (%) | ||
| 1 | 446 (74.5) | 3887 (74.9) |
| 2 | 129 (21.5) | 1252 (24.1) |
| 3+ | 24 (4.0) | 52 (1.0) |
| High-risk conditions, n (%) | ||
| Age ≥70 years | 150 (25.0) | 943 (18.2) |
| Long-term respiratory conditions | 134 (22.4) | 1116 (21.5) |
| Chronic heart disease | 336 (56.1) | 1810 (34.9) |
| Chronic kidney disease | 155 (25.9) | 769 (14.8) |
| Chronic liver disease | 60 (10.0) | 572 (11.0) |
| Diabetes | 169 (28.2) | 1024 (19.7) |
| Weakened immune system caused by medical condition or medication | 122 (20.4) | 780 (15.0) |
| Obesity (class III) | 14 (2.3) | 94 (1.8) |
| Pregnancy | 8 (1.3) | 265 (5.1) |
| Rare disease and inborn errors of metabolism | 8 (1.3) | 265 (5.1) |
| Number of high-risk conditions, n (%) | ||
| 0 | 103 (17.2) | 1617 (31.2) |
| 1 | 123 (20.5) | 1177 (22.7) |
| 2–3 | 263 (43.9) | 1705 (32.8) |
| 4+ | 110 (18.4) | 692 (13.3) |
*Minimum complete vaccination schedule plus at least 1 booster.
IMID, immune-mediated inflammatory disease.