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. 2024 Apr 4;10(2):e004039. doi: 10.1136/rmdopen-2023-004039

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Age at diagnosis and risk of relapse in antineutrophil cytoplasmic antibody-associated vasculitides (AAV), in relation to lead human leucocyte antigen (HLA) variants. The number of risk alleles per patient of HLA-DPB1*04:01 and HLA-DRB1*04:04 was analysed for associations with age at diagnosis of proteinase 3 (PR3)-AAV (A) and myeloperoxidase (MPO)-AAV (B), respectively, and were plotted using Kaplan-Meier curves. Full, dashed and dotted lines correspond to the presence of 0, 1 or 2 risk alleles per patient.