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. 2024 Apr 4;12(4):e006781. doi: 10.1136/jitc-2023-006781

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Pyroptosis-induced antitumor immunity is reliant on BATF3⁺ DCs and T cells (A) Comparison of survival after tumor rechallenge in naïve (N=8) and pyroptosis (N=8) exposed BATF3^−/− or wildtype (N=8) C57bl/6 mice. P values were determined using log-rank (Mantel-Cox) test with Bonferroni correction with significance set at p<0.016. (B) Comparison of survival in naïve and BATF3^−/− pyroptosis exposed mice after adoptive cell transfer of CD8⁺ cells. P values were determined using log-rank (Mantel-Cox) test with significance set at p<0.05. (C) Comparison of survival in naïve or pyroptosis exposed mice with or without CD4 (N=7), CD8 (n=8), or CD4 and CD8 (N=8) T cell depletion. P values were calculated using log-rank (Mantel-Cox) test with Bonferroni correction with significance set at p<0.0033. *** p<0.0001; **** p<0.00001. DC, dendritic cell.