Figure 1.

PCSK9i alleviated atherosclerotic lesions in ApoE−/− mice fed a high-fat diet. (A) The concentrations of TC, TG, LDL-C, and HDL-C in the serum of the four groups of mice were detected using a kit. (B) Histology of HE and oil red O staining in aortic roots of the four groups of mice. (C) Quantification of HE and oil red O staining in aortic roots of the four groups of mice. ApoE−/− mice were fed a high-fat diet to establish an atherosclerosis (AS) mouse model. Data in A and C were analyzed using one-way ANOVA and Tukey’s post-hoc test, *p < 0.05; PCSK9i, Subcutaneous injection of SBC-115076 ApoE−/− mice for 8 weeks; TG, Triglyceride; TC, Total cholesterol; LDL-C, Low-density lipoprotein cholesterol; HDL-C, High-density lipoprotein cholesterol.