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. 2024 Feb 26;11:1284199. doi: 10.3389/fmed.2024.1284199

Figure 2.

Figure 2

Identification of DEMs. (A) Heatmap of miRNA expression in aortic tissues from four groups of ApoE−/− mice. (B–D) The volcano plots show the fold change (FC) and statistical significance of DEMs between each group (B: AS compared to the control; C: PCSK9i compared to the AS; D: Atorvastatin compared to the AS). (E) Venn diagram showing number of genes overlapped in each group. Spots above the horizontal midline represent statistically significant DEMs. FC >1.2 or < 0.833 and p < 0.05 represent the downregulated and upregulated significant DEMs, respectively.