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. 2024 Apr 4;103:105095. doi: 10.1016/j.ebiom.2024.105095

Table 1.

Patient characteristics by occurrence and type of intracranial bleeding event after EVT.

Absenta (n = 67) HBC class 1a + ba (n = 40) HBC class 1c–3aa (n = 18) HBC class 3b–da (n = 7) pb value Overall (n = 132)
Demographic
 Age, median (IQR), y 79 (68–83) 80 (66.5–84) 76.5 (71.5–85.3) 71 (70–81) 0.7 79 (70–83)
Sex
 Male, n (%) 22 (32.8) 14 (35) 6 (33.3) 4 (57.1) 0.97 46 (34.8)
 Female, n (%) 45 (67.2) 26 (65) 12 (66.7) 3 (42.9) 0.97 86 (65.2)
Medical
 Hypertension, n (%) 57 (85.1) 36 (90) 14 (77.8) 7 (100) 0.46 114 (86.4)
 Diabetes mellitus, n (%) 15 (22.4) 8 (20) 3 (16.7) 1 (14.3) 0.86 27 (20.5)
 Hyperlipidemia, n (%) 22 (32.8) 16 (40) 8 (44.4) 1 (14.3) 0.58 47 (35.6)
 Atrial fibrillation, n (%) 38 (56.7) 23 (57.5) 8 (44.4) 4 (57.1) 0.61 73 (55.3)
 Smoking history, n (%) 16 (23.9) 10 (25) 2 (11.1) 2 (28.6) 0.46 31 (23.5)
Baseline medication
 Antithrombotic medication, n (%) 37 (55.2) 23 (57.5) 14 (77.8) 3 (42.9) 0.21 77 (58.3)
 Antiplatelet drugs, n (%) 18 (26.9) 12 (30) 10 (55.6) 0 (0) 0.06 40 (30.3)
 Anticoagulants, n (%) 21 (31.3) 11 (27.5) 5 (27.8) 3 (42.9) 0.9 40 (30.3)
 Antihypertensive drugs, n (%) 56 (83.6) 30 (75) 12 (66.7) 4 (57.1) 0.25 102 (77.3)
Clinical
 NIHSS at presentation, median (IQR) 12 (8–16) 15 (12–18) 16.5 (13–20.5) 9 (6–15) 0.0025 14 (9.3–17)
 Unknown onset, n (%) 20 (29.9) 15 (37.5) 7 (38.9) 3 (42.9) 0.63 45 (34.1)
 ASPECTS at presentation, median (IQR) 9 (8–9) 7 (6–8) 7 (6–8) 9 (8–10) <0.0001 8 (7–9)
 Systolic blood pressure, median (IQR), mmHg 157 (136–180) 160 (144.5–186) 160 (155–183.8) 157 (97.5–164) 0.31 159 (141–180)
 Diastolic blood pressure, median (IQR), mmHg 86 (69–96) 80 (73–98) 89 (78–102.3) 65 (57.5–76.5) 0.11 85 (72–98)
 Heart rate, median (IQR), min−1 81 (70–98) 78 (69.8–89.8) 82.5 (70.5–102.3) 77 (61–98) 0.75 80 (70–97.8)
Treatment
Thrombolysis
 Intravenous alteplase treatment, n (%) 26 (38.8) 15 (37.5) 9 (50) 2 (28.6) 0.64 52 (39.4)
Intervention
 Onset-to-puncture, median (IQR), min 235 (153–325) 230 (156–280) 257 (195–322) 291.5 (147.8–355.8) 0.82 237 (165–316)
 Angiographic occlusion locationc
 M1, n (%) 40 (59.7) 29 (72.5) 11 (61.1) 4 (57.1) 0.4 84 (63.6)
 M2, n (%) 22 (32.8) 3 (7.5) 3 (16.7) 3 (42.9) 0.008 31 (23.5)
 ICA, n (%) 8 (11.9) 10 (25) 4 (22.2) 0 (0) 0.2 22 (16.7)
 Puncture-to-first-pass, median (IQR), min 42.5 (30–51) 38.5 (29–57) 42 (29.5–53.8) 40.5 (35.8–58) 0.92 41 (30–53.3)
 Stent-retrieval manoeuvres, n (IQR) 1 (1–3) 2 (1–3) 1 (1–3.5) 2.5 (1–4) 0.49 2 (1–3)
 Successful recanalisationd, n (%) 58 (86.6) 34 (85) 14 (77.8) 6 (85.7) 0.65 112 (84.9)
 Duration of MT procedure, median (IQR), min 70 (52–104) 89 (62.8–138.3) 74 (53.5–119) 98 (56–154.8) 0.23 75 (56–118)
 Onset-to-final-recanalisation, median (IQR), min 307 (244–425) 325 (264.5–379.5) 319 (280–449) 419 (250–460) 0.74 325 (251.5–408)
Sampling
 Onset-to-cerebral sampling, median (IQR), min 274 (191–375) 285 (192.5–356) 303 (242–442) 243.5 (158.3–355) 0.79 285 (198–367)
 Onset-to-carotid sampling, median (IQR), min 319 (211–405) 342 (277.5–390) 338 (297–460) 366.5 (245.8–475.3) 0.78 336 (263–405)
Outcome
 mRS at discharge, median (IQR) 2 (1–5) 5 (3–5) 6 (5–6) 3 (1–5) <0.0001 4 (1–5)
 Death during hospital stay, n (%) 3 (4.5) 6 (15) 10 (55.6) 1 (14.3) <0.0001 20 (15.2)

ASPECTS, Alberta Stroke Program Early CT Score; EVT, endovascular thrombectomy; HBC, Heidelberg Bleeding Classification; ICA, internal carotid artery; IQR, interquartile range; M1/M2, middle cerebral artery segment; mmHg, millimetres of mercury; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; SD; standard deviation; y, years.

a

Intracranial haemorrhages were anatomically categorised according to the Heidelberg Bleeding Classification (HBC: 1a, haemorrhagic infarction (HI1)—scattered small petechiae; 1b, HI2—confluent petechiae; 1c, parenchymal haematoma (PH1)—haematoma within infarcted tissue, occupying <30%; 2, PH2—haematoma occupying ≥30% of the infarcted tissue; 3a—PH remote from infarcted brain tissue; 3b—intraventricular haemorrhage; 3c—subarachnoid haemorrhage; 3d—subdural haemorrhage) and grouped with respect to the type of bleeding (HBC classes 1a + b, minor [petechial] intracerebral haemorrhage; HBC classes 1c–3a, major intracerebral haemorrhage [parenchymal haematoma]; HBC classes 3b–d, intracranial-extracerebral haemorrhage).

b

The p values for binary variables are based on χ2 test (data for analysis included the following groups: absent, HBC1a + b, and HBC1c–3a). The p values of all other variables are based on Kruskal–Wallis test or one-way ANOVA, as appropriate.

c

Including multiple sites in the target downstream territory.

d

Defined as eTICI ≥ 2b50.