Figure 6.

In vitro autoradiography of [¹¹C]8 binding in mouse brain tissues. (A) Representative autoradiographic images of mice brains (sagittal). The baseline mice brain sections were treated with [¹¹C]8 only, and the blocking mice brain sections were co-treated with [¹¹C]8 and unlabeled 8 (10 μM) and MCC950 (10 μM). (B) Relative radioactive uptake under baseline and blocking conditions. (C) Representative autoradiographic images of mice brains (sagittal) from WT and nlrp3−/− mice. (D) Relative radioactive uptake of [¹¹C]8.