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. Author manuscript; available in PMC: 2024 Apr 9.
Published in final edited form as: J Med Chem. 2023 Dec 27;67(1):555–571. doi: 10.1021/acs.jmedchem.3c01782

Figure 8.

Figure 8.

Baseline and blocking analysis of [11C]8 in C57BL/6 Mouse brains (n=3). (A) Sagittal PET/CT images of [11C]8 in baseline and blocking (1 mg/kg, a structurally unrelated sulfonamide type and unlabeled compound) experiments (summed 30–60 mins). (B) TACs of whole brain uptake of [11C]8. “*” means whole brain radioactivity normalized by maximal blood radioactivity. (C) AUC for TACs of baseline and blocking (30–60 mins, ∼22% reduction in AUC).