Table 2.
Logistic regression for treatment prescription according to latent classes
| Drugs, OR [95%CI] | Low complexity class | CV risk factors class | Atherosclerotic class | Thromboembolic class | Cardiometabolic class | High complexity class |
|---|---|---|---|---|---|---|
| OAC | Ref. | 1.36 [1.24–1.48] | 1.27 [1.11–1.45] | 1.48 [1.27–1.72] | 1.76 [1.49–2.09] | 1.57 [1.35–1.81] |
| NOAC (vs. VKA) | Ref. | 1.21 [1.11–1.31] | 1.03 [0.90–1.17] | 1.20 [1.04–1.37] | 1.12 [0.98–1.29] | 1.18 [1.03–1.35] |
| ACE inhibitors | Ref. | 1.15 [1.07–1.24] | 1.06 [0.94–1.19] | 1.13 [0.99–1.28] | 0.99 [0.87–1.12] | 1.02 [0.90–1.15] |
| Angiotensin receptor blockers | Ref. | 1.13 [1.05–1.22] | 0.96 [0.85–1.09] | 0.86 [0.75–1.00] | 1.00 [0.87–1.14] | 0.97 [0.86–1.11] |
| Diuretics | Ref. | 1.20 [1.11–1.29] | 1.06 [0.94–1.20] | 0.97 [0.85–1.11] | 1.37 [1.20–1.56] | 1.08 [0.95–1.22] |
| Beta-blockers | Ref. | 1.23 [1.15–1.32] | 1.20 [1.06–1.34] | 1.16 [1.03–1.31] | 1.26 [1.11–1.43] | 1.27 [1.13–1.42] |
| Digoxin | Ref. | 0.98 [0.87–1.11] | 0.77 [0.64–0.93] | 0.88 [0.71–1.10] | 0.86 [0.70–1.04] | 1.04 [0.85–1.27] |
| Verapamil/diltiazem | Ref. | 1.00 [0.88–1.14] | 1.56 [1.25–1.95] | 1.18 [0.93–1.49] | 1.84 [1.50–2.26] | 2.43 [2.02–2.93] |
| Class IC antiarrhythmics | Ref. | 1.03 [0.90–1.17] | 0.94 [0.68–1.31] | 1.00 [0.76–1.31] | 0.98 [0.71–1.36] | 0.93 [0.72–1.21] |
| Amiodarone/dronedarone | Ref. | 0.97 [0.88–1.07] | 0.96 [0.83–1.12] | 0.93 [0.77–1.12] | 0.88 [0.74–1.03] | 0.88 [0.75–1.04] |
| Other antiarrhythmics | Ref. | 0.84 [0.72–0.97] | 0.84 [0.68–1.03] | 0.76 [0.57–1.00] | 0.85 [0.67–1.08] | 1.13 [0.90–1.41] |
| Oral hypoglycemic agents | Ref. | 1.42 [1.18–1.71] | 1.24 [0.99–1.56] | 1.27 [0.92–1.76] | 1.41 [1.13–1.77] | 1.67 [1.29–2.17] |
| Insulin | Ref. | 0.92 [0.69–1.22] | 1.09 [0.79–1.50] | 0.75 [0.44–1.26] | 1.43 [1.05–1.94] | 0.99 [0.69–1.42] |
| Proton pump inhibitors | Ref. | 1.20 [1.10–1.30] | 1.32 [1.16–1.50] | 1.55 [1.36–1.77] | 1.66 [1.45–1.90] | 3.72 [3.30–4.19] |
| Statins | Ref. | 4.73 [4.38–5.11] | 4.35 [3.85–4.92] | 2.90 [2.55–3.29] | 8.09 [7.06–9.27] | 5.35 [4.73–6.06] |
Class IC antiarrhythmics includes propafenone and flecainide. Italic values depict results with p < 0.05
ACE angiotensin converting enzyme, OAC oral anticoagulant, NOAC non-vitamin K antagonist oral anticoagulant, VKA vitamin K antagonist