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. 2024 Apr 8;16:53. doi: 10.1186/s13148-024-01660-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Phenotypic age acceleration associates with schizophrenia in women with high PRS. Forest plots showing associations statistics of Horvath Δage (A) and Levine Δage (B) with SCZ PRS stratified by sex. The analyses of Horvath Δage and Levine Δage were subsetted to individuals younger than 40 and older than 31 years, respectively. Analyses were furthermore stratified by sex. Case–control analyses were performed without PRS1 stratification (PRS-all), with cases in the first PRS tercile (PRS-low), cases in the second tercile (PRS-mid), cases in the third tercile (PRS-high), and using PRS1 as continuous variable in cases only. For each analysis, the number of controls and cases included, the regression coefficient, and the P-value are shown. P-values were adjusted for multiple testing (number of tests = 30). The red asterisk highlights analyses that are also significant after permutation (P < 0.05)