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Distribution (upper) and scatterplots by age for the 6,192 clinical specimens submitted for Aβ42/40 testing. (A) Aβ42/40 ratio, Spearman’s rho = −0.25, 95%CI, −0.27 to −0.22. (B) Aβ42 concentrations, Spearman’s rho = 0.22, 95%CI 0.20 to 0.25; and (C) Aβ40 concentrations, Spearman’s rho = 0.41, 95%CI 0.39 to 0.43. Black dashed line denotes Aβ42/40 ratio cutoff of 0.160. Red dotted lines denote Aβ42/40 ratio indeterminant risk cutoffs (0.150 and 0.170). Aβ, beta-amyloid.
