Table 1.
Alzheimer’s Disease Research Center (ADRC) cohort participant characteristics by amyloid positron emission tomography (Aβ PET) status.
| Characteristic | Aβ PET− [N = 149] | Aβ PET+ [N = 101] |
|---|---|---|
| Age (years) (p = 0.150) | ||
| Mean (SD) [N] | 71.6 (7.5) [149] | 73.1 (8.5) [101] |
| Sex (p = 0.794) | ||
| % female [N] | 58.4% [87] | 60.4% [61] |
| Ethnicity (p = 1.000) | ||
| % Hispanic [N] | 59.1% [88] | 58.4% [59] |
| Education (p = 0.234) | ||
| Mean years (SD) | 15.6 (3.2) | 15.1 (3.2) |
| MMSE (P < 0.001) | ||
| % MMSE ≥ 25 [N] | 94.0% [140] | 57.4% [58] |
| Mean (SD) [N] | 28.4 (2.1) [149] | 23.6 (6.2) [101] |
| CDR (P < 0.001) | ||
| % CDR > 0 [N] | 66.4% [99] | 92.1% [93] |
| Plasma Aβ42/40 (P < 0.001) | ||
| Mean (SD) [N] | 0.173 (0.029) [149] | 0.141 (0.017) [101] |
| Plasma Aβ42 (P < 0.001) | ||
| Mean (SD) [N] | 68.3 (17.4) [149] | 58.4 (13.6) [101] |
| Plasma Aβ40 (p = 0.079) | ||
| Mean (SD) [N] | 394.5 (74.7) [149] | 411.5 (74.5) [101] |
| ApoE4+, % (P < 0.001) | ||
| % [N] | 20.8% [31] | 56.4% [57] |
| 18F-florbetaben SUVR (P < 0.001) | ||
| Mean (SD) [N] | 1.020 (0.092) [93] | 1.469 (0.187) [71] |
| 18F-florbetapir SUVR (P < 0.001) | ||
| Mean (SD) [N] | 1.042 (0.068) [26] | 1.455 (0.238) [15] |
Aβ, beta-amyloid; ApoE4, apolipoprotein E4 proteoform; CDR, Clinical dementia rating; MMSE, Mini-mental state exam; SUVR, standardized uptake value ratio.