Table 2.
Association of standing hypotension and standing systolic blood pressure with adverse events: The Atherosclerosis Risk in Communities (ARIC) Study (1987–2019)
| Outcomes | Standing SBP < 110 mm Hg (N = 3,000) vs. SBP ≥ 110 mm Hg (N = 9,467) |
Standing SBP per 10 mm Hg (N = 12,467) |
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Fall | 1.02 (0.94, 1.11) | 0.66 | 1.00 (0.98, 1.02) | 0.83 |
| Syncope | 1.02 (0.93, 1.11) | 0.67 | 1.01 (0.99, 1.03) | 0.30 |
| CHD | 0.88 (0.80, 0.97) | 0.009 | 1.07 (1.05, 1.09) | <0.001 |
| Death | 0.91 (0.86, 0.97) | 0.006 | 1.06 (1.04, 1.07) | <0.001 |
Adjusted for age, sex, race-center, estimated glomerular filtration rate, body mass index, resting heart rate, high-density lipoprotein cholesterol, total cholesterol, prevalent CHD, prior stroke, prevalent heart failure, diabetes mellitus status, hypertension status, self-reported dizziness, alcohol consumption, education level, leisure index, smoking status, antihypertensive medication use in the last two weeks, and use of diuretics, antidepressants, sedatives, hypnotics, antipsychotics, and cholesterol-lowering medications. Participants were followed up through December 31, 2019, for a median of 24 years of follow-up. Abbreviations: CHD, coronary heart disease; SBP, systolic blood pressure.