Table 4.

Association of standing hypotension (<110 mm Hg vs. ≥ 110 mm Hg) with adverse events stratified by baseline 10-year atherosclerotic cardiovascular disease risk: The ARIC Study (1987–2019)

Outcomes	ASCVD < 10% (N = 9,079)	ASCVD ≥ 10% or prior CHD (N = 3,384)	P-value
Fall	1.01 (0.92, 1.11)	1.05 (0.84, 1.31)	0.79
Syncope	1.00 (0.90, 1.10)	1.10 (0.88, 1.38)	0.40
CHD	0.84 (0.74, 0.95)	0.99 (0.84, 1.17)	0.015
Death	0.89 (0.82, 0.96)	1.03 (0.91, 1.17)	0.019

Values are given as hazards ratio (95% confidence interval). Reduced sample size (N = 12,463) for ASCVD analysis due to missing low-density lipoprotein cholesterol data. Models are adjusted for age, sex, race-center, estimated glomerular filtration rate, body mass index, resting heart rate, high-density lipoprotein cholesterol, total cholesterol, prevalent CHD, prior stroke, prevalent heart failure, diabetes mellitus status, hypertension status, self-reported dizziness, alcohol consumption, education level, leisure index, smoking status, antihypertensive medication use in the last two weeks, and use of diuretics, antidepressants, sedatives, hypnotics, antipsychotics, and cholesterol-lowering medications. Participants were followed up through December 31, 2019, for a median of 24 years of follow-up. Abbreviations: ASCVD, baseline 10-year atherosclerotic cardiovascular disease risk; CHD, coronary heart disease; SBP, systolic blood pressure.