Table 4.
Multivariable Cox proportional hazards model for overall survival
| All patients | Univariable analysis | Complete-case multivariable analysis | Imputed multivariable analysis | ||||
|---|---|---|---|---|---|---|---|
| HR* | P | HR* | P | HR* | P | ||
| Age (years), median (i.q.r.) | 66 (59– 71) | 1.01 (1.00, 1.03) | 0.049 | ||||
| Sex | |||||||
| Male | 277 (71.9) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
| Female | 108 (28.1) | 0.68 (0.51, 0.90) | 0.007 | 0.73 (0.51, 1.03) | 0.073 | 0.69 (0.51, 0.92) | 0.013 |
| ASA fitness grade | |||||||
| I | 172 (44.7) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
| II | 141 (36.6) | 1.40 (1.07, 1.83) | 0.013 | 1.30 (0.94, 1.78) | 0.110 | 1.40 (1.07, 1.83) | 0.016 |
| III | 65 (16.9) | 1.65 (1.18, 2.30) | 0.003 | 1.15 (0.75, 1.75) | 0.528 | 1.46 (1.03, 2.07) | 0.033 |
| IV | 7 (1.8) | 2.50 (1.10, 5.69) | 0.029 | 3.63 (1.28, 10.24) | 0.015 | 2.73 (1.13, 6.59) | 0.026 |
| ECOG performance status score | |||||||
| 0 | 273 (70.9) | 1.00 (reference) | |||||
| 1 | 92 (23.9) | 1.13 (0.85, 1.49) | 0.398 | ||||
| 2 | 19 (4.9) | 1.75 (1.06, 2.87) | 0.028 | ||||
| 3 | 1 (0.3) | – | – | ||||
| Smoking status | |||||||
| Non-smoker | 139 (37.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
| Ex-smoker | 160 (42.6) | 0.86 (0.65, 1.12) | 0.266 | 0.82 (0.59, 1.13) | 0.225 | 0.87 (0.66, 1.15) | 0.332 |
| Smoker | 77 (20.5) | 1.08 (0.78, 1.49) | 0.657 | 0.97 (0.64, 1.47) | 0.882 | 1.15 (0.81, 1.63) | 0.431 |
| Tumour site | |||||||
| Oesophagus | 274 (71.2) | 1.00 (reference) | |||||
| Stomach | 111 (28.8) | 0.94 (0.72, 1.22) | 0.638 | ||||
| Histology | |||||||
| AC | 349 (90.6) | 1.00 (reference) | |||||
| SCC | 36 (9.4) | 0.87 (0.57, 1.32) | 0.498 | ||||
| Clinical TNM stage | |||||||
| II | 54 (14.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
| III | 277 (71.9) | 1.69 (1.15, 2.48) | 0.008 | 1.89 (1.19, 3.02) | 0.007 | 1.74 (1.16, 2.59) | 0.007 |
| IV | 54 (14.0) | 1.60 (0.98, 2.59) | 0.059 | 1.54 (0.85, 2.80) | 0.152 | 1.55 (0.93, 2.56) | 0.091 |
| Differentiation (grade) | |||||||
| Poor (G3) | 203 (64.4) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
| Moderate (G2) | 107 (34.0) | 0.65 (0.49, 0.88) | 0.004 | 0.70 (0.51, 0.96) | 0.028 | 0.70 (0.50, 0.98) | 0.036 |
| Well (G1) | 5 (1.6) | 0.34 (0.08, 1.37) | 0.129 | 0.23 (0.03, 1.69) | 0.151 | 0.34 (0.08, 1.43) | 0.142 |
| BMI (kg/m2), median i.q.r.) | 26.1 (23.2–29.4) | 0.98 (0.96, 1.01) | 0.226 | 1.00 (0.97, 1.03) | 0.899 | 0.99 (0.96, 1.02) | 0.453 |
| Cachexia index | |||||||
| Normal | 267 (69.4) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
| Low | 118 (30.6) | 1.84 (1.43, 2.36) | < 0.001 | 1.65 (1.19, 2.29) | 0.003 | 1.85 (1.42, 2.42) | < 0.001 |
Values are n (%) unless otherwise stated; *values in parentheses are 95% confidence intervals. ECOG, Eastern Cooperative Oncology Group; AC, adenocarcinoma; SCC, squamous cell carcinoma.