Table 2. Differences in the most common HLA-A, -B, -C, -DQ, and -DR alleles between patients with benign hematologic disorders and controls.
| Disease | HLA allele | Frequency in patients (%) | Frequency in controls (%) | ORa (95%CI) | P | Pcb |
|---|---|---|---|---|---|---|
| HLH | A*01:01 | 5.30 | 2.68 | 2.04 (1.50–2.76) | <0.01 | 0.02 |
| B*15:01 | 6.75 | 4.39 | 1.57 (1.20–2.07) | <0.01 | 0.04 | |
| C*08:01 | 5.30 | 8.41 | 0.61 (0.45–0.83) | <0.01 | 0.02 | |
| DQB1*03:01 | 16.27 | 20.74 | 0.74 (0.62–0.89) | <0.01 | 0.04 | |
| DRB1*10:01 | 3.61 | 1.46 | 2.54 (1.76–3.66) | <0.01 | 0.02 | |
| AA | A*11:01 | 21.81 | 23.39 | 0.91 (0.86–0.97) | 0.01 | 0.03 |
| B*40:01 | 9.59 | 11.91 | 0.78 (0.72–0.86) | <0.01 | <0.01 | |
| C*07:02 | 14.54 | 16.59 | 0.86 (0.79–0.92) | <0.01 | <0.01 | |
| DQB1*03:03 | 22.82 | 16.42 | 1.51 (1.41–1.60) | <0.01 | <0.01 | |
| DRB1*09:01 | 22.02 | 15.32 | 1.56 (1.46–1.66) | <0.01 | <0.01 | |
| Thalassemia | A*11:01 | 31.68 | 23.39 | 1.52 (1.33–1.73) | <0.01 | <0.01 |
| B*46:01 | 17.76 | 11.45 | 1.67 (1.43–1.96) | <0.01 | <0.01 | |
| C*01:02 | 21.31 | 16.84 | 1.34 (1.15–1.55) | <0.01 | <0.01 | |
| DQB1*05:02 | 22.43 | 8.66 | 3.05 (2.64–3.52) | <0.01 | <0.01 | |
| DRB1*14:54 | 9.25 | 3.56 | 2.76 (2.24–3.40) | <0.01 | <0.01 |
aOR, odds ratio, which describes the odds of cases being HLA alleles carriers to the odds of controls being HLA alleles carriers. Specifically, OR = 1 indicates that the factor has no impact on the occurrence of the disease, OR >1 indicates that the factor is a risk factor, and OR <1 indicates that the factor is protective.
bPc values for multiple comparisons were corrected by Bonferroni’s correction.