Table 1.
Publications using cells and cell derivatives as drug carriers.
| Reference | Cell carrier | Disease | Animal model |
|---|---|---|---|
| Brenner et al. 2018 [34] | Red blood cells | ARDS Pulmonary embolism |
C57BL/6 mouse; LPS i.t. C57BL/6 mouse; Plasma microemboli of fibrin clots i.v. |
| Wan et al. 2018 [35] | Red blood cells | Inflammatory diseases | C57BL/6 mouse |
| Klyachko et al. 2017 [20] | Macrophages | Encephalitis | C57/BL mouse; LPS intracranial |
| Zhang et al. 2018 [19] | Macrophages | Cancer (driven by inflammation) | U87MG tumor-bearing nude mouse |
| Xie et al. 2017 [7] | Macrophages | Melanoma | 1205Lu cell and WM35 cell |
| Xu et al. 2017 [2] | Platelets | B Cell lymphoma | Tumor-bearing BALB/c nude mouse |
| Xu et al. 2017 [3] | Platelets | B Cell lymphoma | Tumor-bearing BALB/c nude mouse |
| Sarkar et al. 2013 [5] | Platelets | Human lung adenocarcinoma | Swiss albino mouse; Ehrlich ascites carcinoma cells i.p. |
| Layek et al. 2018 [14] | Stem cells | Lung carcinoma | SCID beige mouse; A549 cell i.v.; C57BL/6 mouse; Lewis Lung Carcinoma cell i.v. |
| Bagó et al. 2017 [53] | Stem cells | Glioblastoma | Mouse; U87, GBM4, or GBM8 cells stereotactically implanted |
| Hu et al. 2018 [27] | Stem cells | Acute myeloid leukemia | C57BL/6 J mouse; C1498 or WEHI-3 cell i.v. |
| Kim et al. 2016 [4] | Exosomes | Lung carcinoma | C57BL/6 mouse; Lewis lung carcinoma cell i.v. |
| Wang et al. 2017 [32] | Exosomes | Osteoarthritis | C57BL/6 J mouse; Destabilization of medial meniscus surgery |
| Kojima et al. 2018 [60] | Exosomes | Parkinson’s | C57BL/6 J mouse; 6-OHDA solution intracerebral injection |
| Tang et al. 2018 [56] | T Cells | Solid cancers (melanoma and glioblastoma) | C57BL/6 mouse; B16F10 cell s.c. |
| Jones et al. 2017 [23] | T Cells | HIV | NSG mouse; CXCR4-tropic HIV molecular clone LAI i.p. |
| Pohl-Guimarães et al. 2019 [26] | T Cells | Brain tumors | C57BL/6 mouse; B16F10 OVA cell implant |
| Tang et al. 2017 [57] | Synthetic stem cells | Myocardial Infarction | SCID beige mouse; LAD artery ligation |
| Luo et al. 2017 [50] | Synthetic stem cells | Acute myocardial infarction | SCID beige mouse; LAD artery ligation |
| Hu et al. 2015 [28] | RBC mimics/nanovesicles |
Cancer (general) | Nude mouse; MDA-MB-231 cell s.c. |
| Tang et al. 2018 [52] | RBC mimics/nanovesicles |
Myocardial infarction | WKY rat; LAD artery ligation, followed by reperfusion; adult farm pig; LAD coronary balloon occlusion |
| Liang et al. 2018 [40] | RBC mimics/nanovesicles |
Acute liver failure | C57BL/6 mouse; Carbon tetrachloride i.p. |
i.p., intraperitoneal; i.t., intratracheal; i.v., intravenous; s.c., subcutaneous; LAD, left anterior descending.