Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Apr 9;14:8315. doi: 10.1038/s41598-024-58985-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Heatmap of DESeq test results comparing across all groups using the likelihood ratio test implementation (LRT) and comparing diagnostic groups pairwise using Wald test. Analysis included adjustment for BMI, use of anti-diabetic medication (insulin, statins, PPI), and all of the mentioned covariates. Adjustment for metformin was analogous to the overall analysis scheme by removing samples from individuals treated with metformin. The first specified diagnostic group is the reference for the DESeq test in the Wald test. A density plot of the effect sizes (log2fold change) is included with the same color key used in the heatmap. Genera with the lowest p-value in the LRT without adjustment were included, but Log2fold changes and p-values from all genera comparison are provided in Supplementary Table 1. The heatmap was generated with the R package pheatmap with layout adjustments performed in inkscape.