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. 2024 Apr 9;15:3072. doi: 10.1038/s41467-024-47411-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Spatial maps of CD with step size of 0.5 mm for two non-neighboring regions of PTPO. c Histogram of CD for spatial maps depicted above (a, b). d Distribution of positive and negative CD sign and standard deviations from (c) compared with that for a Metropolis-Hastings simulation of an Ising model of two domain orientations. For the Ising model, CD sign given by averaging over 100 trajectories where the substrate affinity per domain area of one orientation is 16 eV mm⁻² and the interdomain coupling per shared edge length is 10 eV mm⁻¹ (details in SI).