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Schematic diagram of the potential role of M2φ‐EVs on ALI/ARDS. Endogenous M2‐like AM‐EVs decreased in LPS‐induced ALI mice model, whilst exogenous M2φ‐EVs alleviated ALI progression primarily by transferring miR‐709 through the NF‐κB/NLRP3 inflammasome axis, with the potential of miR‐709 as a biomarker for assessing ALI/ARDS severity.
