Fig. 2.

A general measure of exposome is significantly associated with cognition across cognitive tasks. We characterized a child’s unique, complex and multidimensional exposome using a general exposome factor (“Exp-Factor”) derived from longitudinal bifactor analysis. The general exposome factor is significantly associated with cognitive performance across all five tasks assessed across both the discovery (A-E) and replication (F-J) samples. One outlier was excluded from Panel A for visualization purposes (Picture Vocabulary score less than −4) but this participant was retained for all statistical analyses.