Table 1.

The general exposome factor is significantly associated with cognition at ages 9–10. Across all five cognitive tasks and across both the discovery and replication sub-samples, the general exposome factor (Exp-Factor) is positively associated with cognition. These effects held with the inclusion of all six orthogonal exposome sub-factors as covariates and survived Bonferroni correction for multiple comparisons. Note that random effects for site and family are also included as covariates in these models.

	Picture Vocabulary				Flanker				Picture Sequence Memory				Pattern Comparison				Reading Recognition
Predictors	β	Std. Error	t	pbonf	β	Std. Error	t	pbonf	β	Std. Error	t	pbonf	β	Std. Error	t	pbonf	β	Std. Error	t	pbonf
Discovery Sample
Intercept	-0.02	0.04	-0.65	1.00	-0.06	0.03	-1.81	7.08 ×10−1	-0.01	0.03	-0.34	1.00	0.05	0.04	1.29	1.00	-0.02	0.05	-0.35	1.00
Age	0.23	0.01	19.88	9.62 ×10−84	0.18	0.01	13.22	2.76 ×10−38	0.11	0.01	8.25	1.93 ×10−15	0.22	0.01	16.48	1.64 ×10−58	0.21	0.01	16.80	1.07 ×10−60
Sex	0.07	0.02	2.81	4.96 ×10−2	0.05	0.03	1.87	6.21 ×10−1	-0.12	0.03	-4.27	1.99 ×10−4	-0.13	0.03	-4.72	2.40 ×10−5	-0.00	0.03	-0.14	1.00
Exp-Factor	0.50	0.01	36.06	4.95 ×10−253	0.20	0.02	13.33	7.06 ×10−39	0.22	0.01	14.85	6.82 ×10−48	0.12	0.02	8.06	9.72 ×10−15	0.43	0.01	28.99	2.90 ×10−170
School	-0.02	0.01	-1.78	7.47 ×10−1	-0.01	0.01	-0.57	1.00	0.02	0.01	1.06	1.00	0.03	0.01	2.03	4.27 ×10−1	-0.00	0.01	-0.18	1.00
Family Values	-0.10	0.01	-7.06	1.91 ×10−11	0.02	0.02	1.49	1.00	-0.03	0.02	-2.10	3.60 ×10−1	0.01	0.02	0.67	1.00	-0.01	0.01	-0.63	1.00
Family Turmoil	0.01	0.01	0.87	1.00	0.01	0.01	0.46	1.00	0.00	0.01	0.13	1.00	-0.02	0.01	-1.17	1.00	0.01	0.01	0.58	1.00
Dense Urban Poverty	0.01	0.01	0.49	1.00	-0.01	0.01	-0.97	1.00	-0.01	0.01	-0.47	1.00	-0.04	0.02	-2.40	1.64 ×10−1	0.05	0.02	3.23	1.25 ×10−2
Extracurriculars	-0.02	0.02	-1.00	1.00	0.01	0.02	0.64	1.00	0.02	0.02	0.92	1.00	-0.01	0.02	-0.32	1.00	-0.01	0.02	-0.45	1.00
Screen Time	-0.03	0.02	-1.62	1.00	-0.03	0.02	-1.57	1.00	-0.12	0.02	-5.49	4.26 ×10−7	-0.04	0.02	-2.03	4.27 ×10−1	-0.08	0.02	-3.82	1.35 ×10−3
Replication Sample
Intercept	-0.05	0.03	-1.37	1.00	-0.04	0.04	-1.10	1.00	0.01	0.03	0.19	1.00	0.03	0.04	0.90	1.00	-0.02	0.05	-0.44	1.00
Age	0.25	0.01	22.01	1.06 ×10−101	0.16	0.01	12.20	9.41 ×10−33	0.11	0.01	8.09	7.69 ×10−15	0.22	0.01	16.05	1.39 ×10−55	0.24	0.01	19.45	2.22 ×10−80
Sex	0.07	0.02	2.89	3.87 ×10−2	0.02	0.03	0.62	1.00	-0.11	0.03	-3.95	7.99 ×10−4	-0.11	0.03	-4.03	5.62 ×10−4	0.04	0.03	1.67	9.58 ×10−1
Exp-Factor	0.48	0.01	36.31	4.80 ×10−256	0.22	0.02	14.76	2.54 ×10−47	0.22	0.01	14.78	1.85 ×10−47	0.15	0.02	9.62	9.75 ×10−21	0.43	0.01	29.58	1.12 ×10−176
School	-0.02	0.01	-1.25	1.00	0.00	0.01	0.23	1.00	0.01	0.01	0.76	1.00	0.06	0.01	4.03	5.66 ×10−4	-0.01	0.01	-1.09	1.00
Family Values	-0.10	0.01	-7.03	2.26 ×10−11	-0.02	0.02	-1.55	1.00	-0.01	0.02	-0.74	1.00	-0.02	0.02	-1.54	1.00	-0.02	0.01	-1.26	1.00
Family Turmoil	-0.01	0.01	-1.15	1.00	-0.00	0.01	-0.25	1.00	0.01	0.01	0.95	1.00	-0.01	0.01	-0.68	1.00	-0.01	0.01	-0.54	1.00
Dense Urban Poverty	-0.00	0.01	-0.32	1.00	-0.02	0.02	-1.53	1.00	-0.04	0.01	-2.70	6.94 ×10−2	0.00	0.02	0.11	1.00	0.02	0.01	1.39	1.00
Extracurriculars	-0.01	0.02	-0.68	1.00	0.01	0.02	0.52	1.00	0.00	0.02	0.08	1.00	-0.00	0.02	-0.11	1.00	-0.02	0.02	-1.02	1.00
Screen Time	-0.06	0.02	-3.22	1.28 ×10−2	-0.03	0.02	-1.28	1.00	-0.08	0.02	-3.79	1.50 ×10−3	-0.07	0.02	-3.07	2.13 ×10−2	-0.06	0.02	-3.21	1.33 ×10−2