Table 1.
Demographic and clinical characteristics of healthy controls and patients with bipolar disorder per analysis. All categorical variables are presented as a percentage over the total number of participants. All continuous variables are presented with the median and the interquartile range. Abbreviations: BMI Body Mass Index; CMV Cytomegalovirus; IDS-C The Inventory of Depressive Symptomatology, Clinician Rating; YMRS Young Mania Rating Scale.
| Healthy Controls | Bipolar Disorder | p-value | |
|---|---|---|---|
| Staining A and B | n = 113 | n = 58 | |
| Female (%) | 69.0% | 50.0% | 0.021 |
| Age | 38.5 (26.9, 50.4) | 43.0 (35.0, 53.5) | 0.12 |
| BMI (kg/m2) | 23.4 (20.7, 25.5) | 25.0 (22.4, 28.1) | 0.0032 |
| CMV seropositive (%) | 35.4% | 39.7% | 0.61 |
| Anti-CMV titers (U/ml) | 5.2 (3.7, 32.4) | 5.0 (3.1, 45.7) | 0.92 |
| IDS-C | – | 7.0 (4.0, 10.8) | – |
| YMRS | – | 0.0 (0.0, 2.0) | – |
| Lithium treated %) | – | 67.2% | – |
| Staining C | n = 38 | n = 50 | |
| Female (%) | 60.5% | 46.0% | 0.31 |
| Age | 37.2 (27.9, 46.0) | 44.2 (32.5, 55.5) | 0.042 |
| BMI (kg/m2) | 22.4 (20.7, 25.0) | 26.1 (22.8, 28.9) | 0.0012 |
| CMV seropositive (%) | 44.7% | 44.0% | 11 |
| Anti-CMV titers (U/ml) | 5.6 (3.8, 36.6) | 4.9 (3.5, 47.7) | 0.72 |
| IDS-C | – | 6.0 (3.2, 9.8) | – |
| YMRS | – | 0.0 (0.0, 2.0) | – |
| Lithium treated (%) | – | 54.3% | – |
| Interleukin-7 analysis | n = 167 | n = 142 | |
| Female (%) | 61.3%) | 56.3% | 0.41 |
| Age | 38.7 (26.8, 52.4) | 45.5 (34.7, 55.0) | 0.022 |
| BMI (kg/m2) | 23.6 (20.9, 25.7) | 24.9 (22.5, 27.9) | < 0.0012 |
| CMV seropositive (%) | 48.8% | 38.4% | 0.21 |
| Anti-CMV titers (U/ml) | 8.0 (3.8, 58.0) | 4.7 (3.5, 45.7) | 0.22 |
| IDS-C | – | 6.0 (4.0, 10.0) | – |
| YMRS | – | 0.0 (0.0, 1.0) | – |
| Lithium treated (%) | – | 58.1% | – |
| Interleukin-7 (pg/ml) | 12.3 (9.3, 16.7) | 10.8 (7.8, 13.7) | < 0.0012 |