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. 2024 Apr 10;9:88. doi: 10.1038/s41392-024-01803-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — a Detailed binding mode of A₂AR in complex with compound 4d (receptor: light gray, ligand: orange, PDB: 3UZA). b SAR study of A₂AR antagonist. c Comparison of the orthosteric binding site of A₂AR–Adenosine complex (light blue, PDB: 2YDO), A₂AR–ZM241385 complex (light yellow, PDB: 4EIY), A₂AR–Compound 4e complex (light green, PDB: 3UZC), the difference in cavity occupation is highlighted by red circles and arrows