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. 2024 Apr 10;9:88. doi: 10.1038/s41392-024-01803-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 18 — a Schematic representation of PAM cinacalcet bound to CaSR (PDB: 7M3F). b Detailed binding modes of CaSR bound to cinacalcet in extended conformations. c Detailed binding modes of CaSR bound to cinacalcet in bent conformations. Hydrogen bonds are presented as orange dashes and π–π stackings are presented as gray dashes