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. 2024 Apr 10;9:88. doi: 10.1038/s41392-024-01803-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 21 — a Schematic representation of the allosteric antagonist BPTU bound to P2Y₁ receptor (PDB code 4XNV). b Detailed binding modes of P2Y₁ receptor bound to BPTU. Hydrogen bonds are presented as orange dashes. c Superimposed views of the highlighted residues on 2MeSADP − P2Y₁R − G₁₁ (pink cartoon, pink sticks; PDB: 7XXH) and P2Y₁R − BPTU structures (blue cartoon, blue sticks; PDB: 4XNV)