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a Superposition of the cocrystal structures of PAM LY3154207 bound to dopamine D1 receptor in upright (pink, PDB: 7CKZ) and boat (yellow, PDB: 7LJC and 7X2F) conformations. b Detailed binding modes of dopamine D1 receptor binding to LY3154207 in upright conformations. c Detailed binding modes of dopamine D1 receptor binding to LY3154207 in boat conformations. Hydrogen bonds are presented as orange dashes; π–π stacking and π–cation stacking interactions are presented as gray dashes
