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. 2024 Apr 10;9:88. doi: 10.1038/s41392-024-01803-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 24 — a Schematic representation of the allosteric antagonist avacopan bound to C5a receptor 1 (PDB: 6C1R). b Detailed binding modes of C5a receptor 1 bound to avacopan. Hydrogen bond is presented as orange dashes. c Superimposed views of highlighted residue Trp213^5.49 on C5aR1–PMX53–avacopan (pink cartoon, pink sticks; PDB: 6C1R) and C5aR1–C5a–G_o (blue cartoon, blue sticks; PDB: 8IA2) structures