Fig. 29.

a Schematic representation of the NAM fenobam bound to mGlu5 receptor (PDB: 5CGC). b Detailed binding modes of mGlu5 receptor binding to compound 14; polar interactions are shown in orange dashes. c SAR optimization of mGlu5 receptor NAMs. d Superimposed views of the highlighted residues on mGlu5–mavoglurant (purple cartoon, purple sticks; PDB: 4OO9), mGlu5–HTL14242 (orange cartoon, orange sticks; PDB: 5CGD), mGlu5–fenobam (blue cartoon, blue sticks; PDB: 6FFH), and mGlu5–CDPPB (pink cartoon, pink sticks; PDB: 8TAO) structures