Fig. 33.
a Schematic representation of PAM BHFF bound to GABAB receptor (PDB: 7C7Q). b Detailed binding modes of GABAB receptor binding to BHFF. Hydrogen bonds are presented by orange dashes. c Superimposed views of the N-terminal α-helix on compound 2–GLP-1R–Gs (blue cartoon, blue sticks; PDB: 7DUR) and GLP-1–GLP-1R–Gs (pink cartoon, pink sticks; PDB: 6×18) structures. d Schematic representation of ago-PAM compound 2 bound to GLP-1R (PDB: 7EVM). e Detailed binding modes of GLP-1R bound to compound 2. f Superimposed views of highlighted residues on compound 2–GLP-1R–Gs (blue cartoon, blue sticks; PDB: 7DUR), GLP-1–GLP-1R–Gs (pink cartoon, pink sticks; PDB: 6×18), and compound 2–GLP-1–GLP-1R–Gs (purple cartoon, purple sticks; PDB: 7DUQ) structures