Fig. 8.
a Detailed binding mode of 5-HT1F in complex with lasmiditan. Hydrogen bonds are presented by orange dashes, while halogen bonds are presented by green dashes. b Superimposed views of 5-HT1A (light green cartoon, PDB: 7E2X), 5-HT1B (light orange cartoon, PDB: 5V54), 5-HT1D (light gray cartoon, PDB: 7E32), 5-HT1E (light pink cartoon, PDB: 7E33), and 5-HT1F (light purple cartoon, PDB: 7EXD). The TM4-ECL2-TM5 region of the 5-HT1F receptor is highlighted for clarity. c The structure alignment comparison of αN helices of G protein coupling with their corresponding 5-HT receptors. αN helix of Gi protein coupled with 5-HT1F is highlighted for clarity. d 2D structure of lasmiditan