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a Detailed binding mode of GnRH1 in complex with elagolix (receptor: light gray, ligand: light pink, PDB: 7BR3), where N-termini of GnRH1R is highlighted in a light purple to present its co-occupation with elagolix in the orthosteric pocket. b Overview of the special signal transduction mechanism in GnRH1R. c 2D structure of elagolix for clarity
