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. 2024 Mar 27;15:1349199. doi: 10.3389/fphar.2024.1349199

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Copyright © 2024 Li, Liu, Deng, Li, Li, Li, Zuo, Shen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSCs from different sources regulate the splenic Th17/Treg balance and bone marrow macrophage polarization through paracrine effects to treat osteoporosis, with DP-MSCs exhibiting the best therapeutic efficacy in this regard.