TABLE 1.
Characteristics of the included patients with acute-on-chronic hepatitis B liver failure.
| Variables | Overall (n = 243) | Non-IFI (n = 219) | IFI (n = 24) | P-value |
| Basic information | ||||
| Gender (%) | 0.496 | |||
| Male | 195 (80.25%) | 177 (80.82%) | 18 (75.00%) | |
| Female | 48 (19.75%) | 42 (19.18%) | 6 (25.00%) | |
| Age, year, (mean ± standard deviation) | 48.23 ± 11.71 | 48.00 ± 11.43 | 50.38 ± 14.09 | 0.347 |
| HBsAg, IU/ml, (Q1, Q3) | 2764.00 (565.13, 6086.00) | 2512.00 (538.79, 6147.50) | 3110.75 (1164.91, 5685.75) | 0.786 |
| HBeAg, s/co, (Q1, Q3) | 14.59 (0.41, 198.74) | 13.84 (0.42, 207.78) | 22.16 (0.31, 133.60) | 0.387 |
| logqHBV DNA | 4.93 (3.94, 6.16) | 4.95 (3.93, 6.06) | 4.78 (4.01, 6.51) | 0.872 |
| Cirrhosis (%) | 0.935 | |||
| No | 93 (38.27%) | 84 (38.36%) | 9 (37.50%) | |
| Yes | 150 (61.73%) | 135 (61.64%) | 15 (62.50%) | |
| Ascites (%) | 0.401 | |||
| No | 73 (30.04%) | 64 (29.22%) | 9 (37.50%) | |
| Yes | 170 (69.96%) | 155 (70.78%) | 15 (62.50%) | |
| Neutrophilic granulocyte percentage,%, (Q1, Q3) | 72.90 (64.45, 81.30) | 72.70 (63.85, 80.70) | 74.80 (71.68, 86.22) | 0.071 |
| Neutrophilic granulocyte percentage category (%) | 0.591 | |||
| 40–75 | 5 (2.06%) | 4 (1.83%) | 1 (4.17%) | |
| <=40 | 130 (53.50%) | 119 (54.34%) | 11 (45.83%) | |
| >=75 | 108 (44.44%) | 96 (43.84%) | 12 (50.00%) | |
| Neutrophilic granulocyte, 10^9/l, (Q1, Q3) | 5.10 (3.25, 7.65) | 4.97 (3.16, 7.63) | 6.46 (3.74, 9.20) | 0.218 |
| Neutrophilic granulocyte category (%) | 0.266 | |||
| 1.8–6.3 | 14 (5.76%) | 13 (5.94%) | 1 (4.17%) | |
| <=1.8 | 144 (59.26%) | 133 (60.73%) | 11 (45.83%) | |
| >=6.3 | 85 (34.98%) | 73 (33.33%) | 12 (50.00%) | |
| Length of hospitalization, day, (Q1, Q3) | 13.00 (9.00, 20.50) | 13.00 (9.00, 19.50) | 21.50 (16.75, 28.50) | <0.001 |
| Sodium, mmol/l, (Q1, Q3) | 136.00 (132.00, 138.00) | 136.00 (132.00, 139.00) | 134.50 (131.00, 136.00) | 0.024 |
| Procalcitonin, ng/ml, (Q1, Q3) | 0.46 (0.29, 0.82) | 0.44 (0.29, 0.82) | 0.57 (0.38, 1.20) | <0.001 |
| Liver function | ||||
| Alanine aminotransferase, U/l, (Q1, Q3) | 142.00 (74.00, 354.50) | 145.00 (74.50, 354.50) | 140.50 (73.50, 322.75) | 0.510 |
| Alanine aminotransferase category (%) | 0.824 | |||
| <=50 | 34 (13.99%) | 31 (14.16%) | 3 (12.50%) | |
| >50 | 209 (86.01%) | 188 (85.84%) | 21 (87.50%) | |
| Aspartate aminotransferase, U/l, (Q1, Q3) | 128.00 (78.50, 237.50) | 128.00 (80.50, 237.00) | 121.00 (74.75, 273.00) | 0.668 |
| Aspartate aminotransferase category (%) | 0.716 | |||
| <=40 | 16 (6.58%) | 14 (6.39%) | 2 (8.33%) | |
| >40 | 227 (93.42%) | 205 (93.61%) | 22 (91.67%) | |
| Total bilirubin, umol/l, (Q1, Q3) | 274.00 (199.00, 399.15) | 271.50 (193.65, 399.15) | 286.80 (235.72, 402.90) | 0.245 |
| Total bilirubin category (%) | 0.114 | |||
| <=181 | 63 (25.93%) | 60 (27.40%) | 3 (12.50%) | |
| >181 | 180 (74.07%) | 159 (72.60%) | 21 (87.50%) | |
| Albumin, g/l, (Q1, Q3) | 33.20 (30.30, 35.80) | 33.20 (30.30, 35.80) | 33.40 (30.65, 35.60) | 0.761 |
| Albumin category (%) | 0.218 | |||
| 40–55 | 16 (6.58%) | 13 (5.94%) | 3 (12.50%) | |
| <=40 | 227 (93.42%) | 206 (94.06%) | 21 (87.50%) | |
| Globulin, g/l, (Q1, Q3) | 27.80 (23.45, 34.15) | 28.40 (24.05, 34.35) | 24.50 (20.43, 30.95) | 0.075 |
| Globulin category (%) | 0.122 | |||
| <=40 | 223 (91.77%) | 199 (90.87%) | 24 (100.00%) | |
| >40 | 20 (8.23%) | 20 (9.13%) | 0 (0.00%) | |
| Kidney function | ||||
| Creatinine, μmol/l, (Q1, Q3) | 59.00 (48.00, 71.00) | 59.00 (48.50, 71.00) | 55.00 (41.25, 66.50) | 0.823 |
| Coagulation function | ||||
| Prothrombin time activity, %, (Q1, Q3) | 33.00 (26.00, 43.00) | 33.00 (26.00, 43.00) | 33.00 (26.75, 42.50) | 0.972 |
| International normalized ratio, (Q1, Q3) | 2.10 (1.70, 2.64) | 2.11 (1.68, 2.66) | 1.98 (1.78, 2.49) | 0.821 |
| International normalized ratio category | 0.541 | |||
| <=1.5 | 169 (69.55%) | 151 (68.95%) | 18 (75.00%) | |
| 1.5–2.5 | 74 (30.45%) | 68 (31.05%) | 6 (25.00%) | |
| Nervous system | ||||
| Hepatic Encephalopathy (%) | 0.611 | |||
| No | 182 (74.90%) | 163 (74.43%) | 19 (79.17%) | |
| Yes | 61 (25.10%) | 56 (25.57%) | 5 (20.83%) | |
HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; IFI, invasive fungal infection; HBV DNA, hepatitis B virus deoxyribonucleic acid. logqHBV DNA, logarithm of serum HBV DNA quantification.