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. 2024 Mar 27;15:1391814. doi: 10.3389/fmicb.2024.1391814

TABLE 2.

Characteristics of IFI patients.

Characteristics Overall (n = 24) Survival (n = 3) Non-survival (n = 21) P-value
Gender (%) 0.285
Male 18 (75.00%) 3 (100.00%) 15 (71.43%)
Female 6 (25.00%) 0 (0.00%) 6 (28.57%)
Age category, year (%) 0.089
<=48 13 (54.17%) 3 (100.00%) 10 (47.62%)
>48 11 (45.83%) 0 (0.00%) 11 (52.38%)
Age 48.0 (38.8, 61.5) 37.0 (34.5, 39.0) 49.0 (41.0, 66.0) 0.054
IFI diagnosis time days continuous, day 17.50 (13.50, 23.00) 25.00 (17.00, 57.00) 17.00 (14.00, 21.00) 0.037
Treatment time continuous, day 5.00 (2.00, 8.50) 16.00 (10.50, 29.00) 5.00 (1.75, 5.50) 0.012
Length of hospitalization continuous, day 21.50 (16.75, 28.50) 41.00 (27.50, 86.00) 21.00 (17.00, 26.00) 0.004
HBsAg category (%) 0.118
<=2700 10 (41.67%) 0 (0.00%) 10 (47.62%)
>=2700 14 (58.33%) 3 (100.00%) 11 (52.38%)
HBeAg status (%) 0.19
Negative 8 (33.33%) 0 (0.00%) 8 (38.10%)
Positive 16 (66.67%) 3 (100.00%) 13 (61.90%)
HBV DNA statue (%) 0.008
Negative 1 (4.35%) 1 (33.33%) 0 (0.00%)
Positive 22 (95.65%) 2 (66.67%) 20 (100.00%)
Neutrophilic granulocyte percentage category (%) 0.132
40–75 1 (4.17%) 0 (0.00%) 1 (4.76%)
<=40 11 (45.83%) 3 (100.00%) 8 (38.10%)
>=75 12 (50.00%) 0 (0.00%) 12 (57.14%)
Neutrophilic granulocyte category, 10^9/l 0.026
1.8–6.3 1 (4.17%) 1 (33.33%) 0 (0.00%)
<=1.8 11 (45.83%) 1 (33.33%) 10 (47.62%)
>=6.3 12 (50.00%) 1 (33.33%) 11 (52.38%)
Total bilirubin, umol/l 286.80 (235.72, 402.90) 202.20 (190.55, 235.25) 305.50 (251.40, 445.80) 0.164
Globulin, g/l 24.50 (20.43, 30.95) 30.50 (28.15, 34.30) 22.70 (19.30, 29.10) 0.188
Alanine aminotransferase category, U/l 0.091
<=50 3 (12.50%) 0 (0.00%) 3 (14.29%)
>50 10 (41.67%) 3 (100.00%) 7 (33.33%)
2 11 (45.83%) 0 (0.00%) 11 (52.38%)
Procalcitonin category, ng/ml 0.335
<=0.1 3 (15.00%) 1 (33.33%) 2 (11.76%)
>0.1 17 (85.00%) 2 (66.67%) 15 (88.24%)
Use of antibiotics (%) 0.699
No 1 (4.17%) 0 (0.00%) 1 (4.76%)
Yes 23 (95.83%) 3 (100.00%) 20 (95.24%)
Use of glucocorticoids (%) 0.342
No 5 (20.83%) 0 (0.00%) 5 (23.81%)
Yes 19 (79.17%) 3 (100.00%) 16 (76.19%)
Creatinine, μmol/l 55.00 (41.25, 66.50) 37.00 (35.00, 46.00) 55.00 (46.00, 68.00) 0.477
Hemoptysis (%) 0.007
No 23 (95.83%) 2 (66.67%) 21 (100.00%)
Yes 1 (4.17%) 1 (33.33%) 0 (0.00%)
Dyspnea (%) 0.285
No 18 (75.00%) 3 (100.00%) 15 (71.43%)
Yes 6 (25.00%) 0 (0.00%) 6 (28.57%)
Pleuritic chest pain (%) 0.007
No 23 (95.83%) 2 (66.67%) 21 (100.00%)
Yes 1 (4.17%) 1 (33.33%) 0 (0.00%)

HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; IFI, invasive fungal infection; HBV DNA, hepatitis B virus deoxyribonucleic acid.