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. 2024 Mar 27;15:1384227. doi: 10.3389/fphar.2024.1384227

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Copyright © 2024 Li, Dong, Meng, Xiong, Wu, Ma and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PA prolonged the lifespan of C. elegans and required FOXO/DAF-16. (A–C) Survival curves of daf-16 (mu86)I., akt-1 (ok525)v., and akt-2 (ok393)X (mean ± SD, n ≥ 3; t-test). (D,E) Representative images and quantification demonstrating the effect of 200 μM PA on daf-16 nuclear localization in the TJ356 strain. (F) Relative expression levels of downstream genes regulated by daf-16 in the wild-type N2 L4 stage and mutant CF1038 treated with 200 μM PA for 24 h (mean ± SD, n ≥ 3; *p < 0.05, **p < 0.01, ***p < 0.001; NS, not significant; t-test).