Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 27;15:1384227. doi: 10.3389/fphar.2024.1384227

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Li, Dong, Meng, Xiong, Wu, Ma and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

PA extends the lifespan of C. elegans and modulates lipid metabolism via the mitochondrial pathway. (A–C) Survival curves of the mitochondrial dysfunction mutants isp-1, clk-1, and aak-2 treated with 200 μM PA (mean ± SD, n ≥ 3; log-rank test). (D) Relative expression levels of mitochondrial genes in N2 worms after 24 h of treatment with 200 μM PA (mean ± SD, n ≥ 3; **p < 0.01 and ***p < 0.001; t-test). (E,F) Effects of wild-type N2 on fat content analyzed with or without 200 μM PA (mean ± SD, n ≥ 30; **p < 0.01; t-test). (G) mRNA expression levels related to fat metabolism genes were assessed after 24 h of treatment with 200 μM PA (mean ± SD, n ≥ 3; ***p < 0.001; ns, not significant; t-test).