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. 2024 Mar 27;15:1384227. doi: 10.3389/fphar.2024.1384227

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Copyright © 2024 Li, Dong, Meng, Xiong, Wu, Ma and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PA extended the lifespan of C. elegans through the autophagy pathway. (A,B) Survival curves of mutant RNAi atg-18 and RNAi bec-1 with or without 200 μM PA (mean ± SD, n ≥ 30; log-rank test). (C,D) Representative images and quantification of BC12921 (SQST-1) treated with PA for 3, 5, and 7 (mean ± SD, n ≥ 30; **p < 0.01; ns, not significant; t-test). (E,F) Representative images and quantification of DA2123 (lgg-1) treated with 200 μM PA for 48 h (mean ± SD, n ≥ 30; ***p < 0.001; t-test). (G) Relative expression analysis of autophagy-related genes after treatment with 200 μM PA for 24 h (mean ± SD, n ≥ 3; ***p < 0.001; t-test). (H,I) S6K protein expression remained unchanged following PA treatment (mean ± SD, n ≥ 3; ***p < 0.001; log-rank test).