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Expressions of de novo HBP enzymes are increased in AML. AML LSCs show increased oxidative phosphorylation and AML blasts show increased glycolysis (11). This study shows that HBP is increased both in AML LSCs and AML blasts. De novo HBP in AML may utilize the rate limiting step enzyme GFAT1. OGT is elevated in AML. Expression of salvage HBP enzyme NAGK is decreased in AML Created with BioRender.
