Figure 2. Prevalence of Analgesic Use During Pregnancy and Neurodevelopmental Disorder Incidence (N = 2 480 797 Children).

Prevalence of analgesic use during pregnancy was 185 909 (7.5%) for acetaminophen, 39 811 (1.6%) for aspirin, 61 597 (2.5%) for nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs), 81 970 (3.3%) for opioid medications, and 19 687 (0.8%) for antimigraine medications. Cumulative incidence of neurodevelopmental disorders was 68 584 (2.8%) for autism, 146 386 (5.9%) for attention-deficit/hyperactivity disorder (ADHD), and 24 554 (1.0%) for intellectual disorder.