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. 2024 Mar 27;6(2):fcae105. doi: 10.1093/braincomms/fcae105

Figure 3.

Figure 3

Structural neuroimaging results. (A) Results of region of interest voxel-based morphometry analysis of cerebellum IV, V and VI grey matter. Groups were compared using ANCOVA adjusted for age, sex, total intracranial volume and weighted image quality (19 patients with DYT-SGCE and 24 healthy volunteers). Groups differed for the left cerebellum IV-V-VI (F(1,37) = 10.76, pcorr = 0.004) and the right cerebellum IV-V-VI: F(1,37) = 8.67, pcorr = 0.01). (B) Partial correlation accounting for the effect of age, sex, total intracranial volume, weighted image quality and the judgment of performance in the ‘control’ condition during the explicit agency task in DYT-SGCE group of individual left (in purple, r = −0.76, P = 0.002) and right (in green, r = −0.72, P = 0.004) cerebellum IV, V and VI voxel-based morphometry signals on y-axis (corrected for covariable of non-interest) and the summary agency scores in the ‘Lag’ condition on x-axis. (C) Results of region of interest MD analysis of cerebellum IV, V and VI grey matter. Groups were compared using ANCOVA adjusted for age, sex, total intracranial volume and absolute motion (19 patients with DYT-SGCE and 24 healthy volunteers). Groups differed for the left motor cerebellum (F(1,37) = 6.84, pcorr = 0.03). (D) Partial correlation accounting for the effect of age, sex, total intracranial volume, absolute motion, and the judgment of performance in the control condition during the explicit agency task in DYT-SGCE group of individual left (in purple, r = −0.61, P = 0.02) cerebellum IV, V, and VI MD on y-axis (corrected for covariable of non-interest) and the summary agency scores in the ‘Lag’ condition on x-axis. DYT-SGCE, myoclonus dystonia; HV, healthy volunteers; VBM, voxel-based morphometry; MD, diffusion tensor imaging mean diffusivity. DeltaJoLag = summary agency score in the ‘Lag’ condition. *Significant results (P < 0.05). NS, non-significant.